Spermidine trihydrochloride is the hydrochloride salt structure of spermidine, a polyamine compound, It is a longevity agent in mammals due to sustain functions, including apoptosis, cell growth, cell proliferation, and DNA stability.
1.the regulation of various biological processes, intracellular pH and membrane potential.
2.number of important biological processes, aspartate receptors and cGMP/PKG pathway activation.
3.plays an important role in how long cells and living tissues live.
Anti-aging, improve immunity, protect cardiovascular system, support stem cells, improve Alzheimer's cognition, improve reproductive health
High Quality Chinese Factory supply 334-50-9 Spermidine
- Molecular Formula:C7H19 N3 . 3 Cl H
- Molecular Weight:254.631
- Appearance/Colour:white crystalline powder
- Vapor Pressure:0.0269mmHg at 25°C
- Melting Point:257-259 °C(lit.)
- Boiling Point:246.6 °C at 760 mmHg
- Flash Point:118.1 °C
- PSA：64.07000
- Density:0.906 g/cm3
- LogP:3.86120
SPERMIDINE TRIHYDROCHLORIDE(Cas 334-50-9) Usage
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Biological Activity
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Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801. Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.
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Purification Methods
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Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]
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General Description
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Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.
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InChI:InChI=1/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
334-50-9 Relevant articles
Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy
Tachikawa, Shoji,Miyoshi, Tatsuro,Koganei, Hayato,El-Zaria, Mohamed E.,Vias, Clara,Suzuki, Minoru,Ono, Koji,Nakamura, Hiroyuki
, p. 12325 - 12328 (2014)
closo-Dodecaborate-encapsulating liposom...
Synthesis process of spermidine and intermediate thereof
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Paragraph 0047-0053, (2021/10/27)
The invention provides a synthesis proce...
Method for synthesizing spermidine hydrochloride
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Paragraph 0024-0025; 0034; 0036; 0037; 0039, (2020/07/13)
The invention relates to a method for sy...
Synthesis of 13C-dilabeled 4-coumaroylspermidines
Geneste, Herve,Hesse, Manfred
, p. 15199 - 15214 (2007/10/03)
Five 13C-dilabeled constitution isomers ...
334-50-9 Process route
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N-(3-azidopropyl)-1,4-diaminobutane
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- 334-50-9,35408-56-1
spermidine trihydrochloride
Conditions
| Conditions |
Yield |
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With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 3102.9 Torr; Ambient temperature;
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91% |
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- 191277-07-3
tert-butyl {4-{[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate
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- 334-50-9,35408-56-1
spermidine trihydrochloride
Conditions
| Conditions |
Yield |
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tert-butyl {4-{[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate; With hydrazine hydrate; In ethanol; for 4h; Reflux; Large scale;
With hydrogenchloride; In ethanol; water; Reagent/catalyst; Reflux; Large scale;
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78.9% |
334-50-9 Upstream products
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130750-16-2
{3-[4-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-butylamino]-propyl}-carbamic acid tert-butyl ester
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81065-67-0
N,N',N''-tris(phenylaminothiocarbonyl)-N-(3-aminopropyl)-1,4-diaminobutane
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182576-24-5
tert butyl (4 aminobutyl)(3-aminopropyl)carbamate
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124-20-9
N-(3-aminopropyl)-1,4-diaminobutane
334-50-9 Downstream products
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189340-47-4
N1,N4,N8-tris(mesitylenesulfonyl)spermidine
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131086-79-8
3-(4-methoxy-phenyl)-N-{4-[3-(4-methoxy-phenyl)-acryloylamino]-butyl}-N-{3-[3-(4-methoxy-phenyl)-acryloylamino]-propyl}-acrylamide
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2465-97-6
N-(4-guanidinylbutyl)-N-(3-guanidinylpropyl)amine
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131086-78-7
N1,N5,N10-tri-<(E)-p-coumaroyl>-spermidine
