Nervonic acid is a long-chain monounsaturated fatty acid, also known as shark acid or cis-15-tetradecenoic acid (C24:1). It is a core component of brain nerve fibers and nerve cells. It is mainly found in the nerve tissue and brain tissue of mammals and is an important substance that constitutes the nerve cell membrane. Nervonic acid cannot be synthesized by the human body and must be ingested through food. Therefore, maintaining a reasonable diet intake is essential for maintaining brain health.
Factory Export Top Purity Nervonic Acid 506-37-6 In Stock
- Molecular Formula:C24H46 O2
- Molecular Weight:366.628
- Appearance/Colour:clear to yellowish crystalline powder
- Vapor Pressure:1.68E-10mmHg at 25°C
- Melting Point:42 - 44 C
- Refractive Index:1.4806 (estimate)
- Boiling Point:479.2ºC
- PKA:4.78±0.10(Predicted)
- Flash Point:>110 ºC
- PSA：37.30000
- Density:0.887g/cm3
- LogP:8.44910
Nervonic acid(Cas 506-37-6) Usage
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Preparation
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Nervonic acid was shown to be identical with selachaleic acid isolated from whale oils. It is obvious that nervonic acid is probably the cis form of erucylacetic acid. Erucylacetic acid has been prepared from erucyl alcohol through the bromide and malonic ester synthesis and has been shown to be identical with nervonic acid obtained from hydrolysis of the cerebroside isolated from human brains.Nervonic acid is also produced from oleic acid, that undergoes three consecutive chain elongation steps, catalyzed by elongases.Two carbon units are added in each step, with production of gadoleic acid, erucic acid, and finally, nervonic acid.
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Biochem/physiol Actions
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Nervonic acid (C24:1), a component of membrane sphingolipids and phosphatidylethanolamines, may be a useful predictor of chronic kidney disease mortality and diabetes. Nervonic acid oils are being studied for pharmaceutical, nutraceutical and industrial applications. Nervonic acid is a major component of Lunaria oil.
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Source
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Sources of Nervonic acid include oil crop seeds, oil-producing microalgae and other microorganisms. Transgenic technology can also be used to improve the source and production of Nervonic acid.
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Definition
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ChEBI: Nervonic Acid is a monounsaturated fatty acid with a 24-carbon backbone and the sole double bond originating from the 9th carbon from the methyl end, with this bond in the cis- configuration. It is a metabolite found in the aging mouse brain.
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General Description
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Nervonic acids are the products of desaturation and elongation processes of various fatty acids such as palmitic acid, stearic acid, oleic acid, etc.
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InChI:InChI=1/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-
506-37-6 Relevant articles
A Facile and Efficient Method for the Synthesis of Labeled and Unlabeled Very Long Chain Polyunsaturated Fatty Acids
Hamberg, Mats
, p. 489 - 494 (2021/04/19)
Several methods are available for elonga...
Preparation method of nervonic acid and nervonic acid
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Paragraph 0062-0066, (2020/07/27)
The invention discloses a preparation me...
NOVEL PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS
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Page/Page column 15, (2010/02/11)
The invention relates to phospholipid-li...
506-37-6 Process route
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- 50995-29-4
1-hydroxy-cis-15-tetracosene
Conditions
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Yield |
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With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 7h;
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70% |
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- 2733-88-2
methyl cis-tetracos-15-enate
Conditions
| Conditions |
Yield |
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With sodium hydroxide; In ethanol; at 60 ℃; for 1h; Inert atmosphere;
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506-37-6 Upstream products
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111924-39-1
(Z)-22-bromo-9-docosene
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996-82-7
sodium diethylmalonate
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112-80-1
cis-Octadecenoic acid
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629-98-1
erucyl alcohol
506-37-6 Downstream products
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1460-18-0
pentadecanedioic acid
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557-59-5
n-tetracosanoic acid
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115863-91-7
tetracos-15t-enoic acid
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112-05-0
nonanoic acid
