Tributyrin

Product_introduction

What is Tributyrin?

Tributyrin (also known as Glyceryl Tributyrate, CAS No. 60-01-5) is a triglyceride composed of glycerol esterified with three molecules of butyric acid. It appears as a colorless to pale yellow oily liquid with excellent chemical stability.

As a highly efficient butyric acid precursor, tributyrin offers distinct advantages over free butyric acid or butyrate salts. It effectively masks the pungent odor of butyric acid and releases butyrate gradually under the action of digestive enzymes, improving palatability and bioavailability.

Glyceryl Tributyrate Typical Physicochemical Properties:

Mechanism of Tributyrin Action

After oral administration, tributyrin is hydrolyzed by lipases to release glycerol and butyric acid. The released butyrate acts through multiple pathways:

• Provides energy for colonic epithelial cells

• Supports intestinal barrier function

• Helps maintain gut microbiota balance

• Regulates epigenetic processes via histone deacetylase (HDAC) inhibition

• Supports immune and metabolic health

Compared to other butyrate supplements such as sodium butyrate, tributyrin offers superior palatability, enhanced stability, and sustained-release properties.

Recommended Tributyrin Dosage & Formats

Tributyrin is compatible with a wide range of product formats and works synergistically with probiotics:

Our Solid Forms – Expanding Formulation Possibilities:
We offer tributyrin in solid formats (microencapsulated powder or silica‑adsorbed powder) that are especially well‑suited for tablets, hard capsules, and stick‑pack sachets. This allows you to develop diversified finished products beyond traditional liquids and softgels, meeting the needs of different consumer segments.

Actual addition levels should be determined based on regulatory requirements and product positioning.

Regulatory & Safety Status

Tributyrin has been extensively used in nutritional and biomedical research. Toxicological data demonstrate a favorable safety profile under reasonable usage conditions.

• FDA Status: Tributyrin is affirmed as Generally Recognized as Safe (GRAS) as a direct human food ingredient under 21 CFR § 184.1903. It is listed in the FDA's Substances Added to Food (EAFUS) database and recognized by the Flavor and Extract Manufacturers Association (FEMA) as GRAS (FEMA No. 2223). The ingredient may be used in food with no limitation other than current good manufacturing practice (CGMP), including applications in baked goods, alcoholic and nonalcoholic beverages, fats and oils, frozen dairy desserts, gelatins, puddings, soft candy, and more.

• EFSA / JECFA Status: The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has evaluated tributyrin and concluded that there is "no safety concern at current levels of intake" when used as a flavoring agent. EFSA has also recognized this status.

• TGA Status: For products intended for the Australian market, compliance with Therapeutic Goods Administration (TGA) requirements is recommended. TGA certification is required for therapeutic products and dietary supplements marketed in Australia.

• Our Production Qualification: We hold a valid Food Production License (SC certification), ensuring that all tributyrin raw materials and finished blends are manufactured in full compliance with national food safety standards. This gives you the confidence of a traceable, audited supply chain.

Key Research Areas Include:

• Gut health support

• Intestinal barrier maintenance

• Gut microbiota modulation

• Sports nutrition

• Healthy aging

• Clinical nutrition support

Where Tributyrin come from

Industrial production of tributyrin typically involves esterification of high-purity butyric acid with glycerol, followed by purification to obtain high-quality product.

Our Microencapsulation Advantage:
We employ advanced microencapsulation technology (in addition to silica adsorption) for our solid‑form products. The microcapsule structure effectively traps the characteristic pungent odor of butyric acid derivatives, dramatically reducing off‑notes and significantly improving the taste and mouthfeel of the final product. This is especially critical for gummies, chewable tablets, and oral dissolving strips, where sensory experience directly influences consumer acceptance.

Standard Quality Control Parameters:

• Purity analysis

• Acid value

• Moisture content

• Heavy metals

• Residual solvents

• Microbiological indicators

Storage: 

Recommended to keep in sealed containers, stored in a cool, dry, and dark environment.

Who need Tributyrin the most

Tributyrin is suitable for individuals focused on the following health needs:

• Those prioritizing gut health

• Individuals seeking to improve gut microbiota balance

• Athletes and fitness enthusiasts

• Middle-aged and senior consumers

• Those concerned with metabolic health

• Consumers seeking short-chain fatty acid supplementation solutions

Health Benefits of Glyceryl Tributyrate

A growing body of research suggests that tributyrin may contribute to:

• Maintaining intestinal epithelial integrity

• Supporting colon health

• Promoting a healthy inflammatory balance

• Maintaining gut microbiota diversity

• Enhancing nutrient absorption efficiency

• Improving gastrointestinal comfort

• Supporting cellular energy metabolism

• Promoting overall digestive system health

These effects are subject to ongoing research; individual results may vary.

Bulk Tributyrin Global Supply & Customization Services 

We are a licensed food ingredient manufacturer with full SC certification. Our tributyrin portfolio includes both liquid and solid grades.

Why choose us Leadingnutra

Here is what sets us apart:

• ✔ Licensed Production – We hold a Food Production License (SC), guaranteeing that every batch meets Chinese national food safety standards and is traceable from raw material to finished product.

• ✔ Solid Forms for Versatile Dosing – Our microencapsulated and silica‑adsorbed powders are designed for easy incorporation into tablets, hard capsules, sachets, and other dry formats, giving you maximum flexibility in product development.

• ✔ Odor‑Masking Microencapsulation – The microcapsule structure not only stabilizes tributyrin but also dramatically reduces the characteristic unpleasant smell, delivering a much more pleasant taste experience in your final formulations.

In addition, we support:

• Food‑grade raw material supply

• Customizable purity specifications

• Bulk packaging solutions

• OEM/ODM services

• Technical documentation support

• Third‑party testing reports

• Flexible minimum order quantities (MOQ)

• Formulation development support

• Custom premix and compounding solutions

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